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Ten patients, who received cadaveric kidneys, were followed for 24 wk with serial measurements of serum erythropoietin (S-Epo), transferrin receptor (S-TfR) and iron variables. The mean pretransplant creatinine clearance was 8.2 (range 0-22) ml/min and the mean haemoglobin (Hb) level was 99 +/- 18.6 (range 66-124) g/l. Nine patients demonstrated a gradual increase in S-Epo levels, which reached a peak, and was accompanied by a parallel increase in S-TfR levels with a median lag period of 3 wk between both peaks. Hb correction followed the S-TfR peak after a second lag period (median 7 wk). Elevated S-Epo and S-TfR did not result in correction of anaemia in 1 patient due to impaired graft function. Within 4 months, S-Epo levels reached the normal range while TfR levels were higher than normal. Follow-up of iron status demonstrated the development of iron deficiency in 5 patients, which was corrected spontaneously. Improvement in erythropoiesis after renal transplantation seems to occur by means of expansion of the erythroid marrow, as detected by increasing S-TfR levels, subsequent to a S-Epo peak. This expansion precedes Hb normalization. A nonuraemic environment is probably a prerequisite for the correction of anaemia but not for the increase in S-Epo or S-TfR levels. Iron deficiency may occur after transplantation due to an increase in iron utilization.
N/A / Link / Beshara , Soheir / 1997

Uppsala universitet Övrigt
N/A / Link / Miculan , Marino / 2005

Many of the anticipated benefits from IT investments in health care have still not materialized. This is certainly true in many industries and organizations, and the reasons behind this development are many. However, health care is somewhat special in the sense that most health care organizations are still functional organizations, instead of focusing on patient value through the entire care process. This, together with questionable IT handling, might begin to explain why possible IT benefits in health care, still, are elusive. Furthermore, today, health care professionals and managers – especially on top managementl evels – often claim that their organizations in fact are “process oriented”, and that one should approach health care from a process perspective in order to utilize the present IT related benefits; such as increased service quality, cost efficiency, and enhanced communication. In this paper we investigate how well founded the concept of process orientation really is – by examining IT/IS infrastructures, and procedures for process definition, visualization, andevaluation – at a prominent hospital in Stockholm, Sweden. A case study ofthe organization and interaction of the emergency and radiology departments at the same hospital (using process mapping and data analysis) reveals data fragmentation, incompatible data, and disparate information systems. Resulting in difficulties regarding process definition and analysis. This, in turn, makes the use of innovative IT-based tools such as simulation, problematic. The implications of this, and the contextual factors, are also discussed and some final recommendations for smooth digitization are put forth.
N/A / Link / Fryk , Pontus /

N/A / Link / Welch , Kenneth / 2009

Uppsala universitet Nordiska Språk
978-91-977030-0-0 / Link / Williams , Henrik / 2007

Uppsala universitet Nordiska Språk
N/A / Link / Williams , Henrik / 2007

Uppsala universitet Samhällsvetenskap
N/A / Link / Magnusson Turner , Lena / 2008

N/A / Link / Turner , Bengt / 2007

N/A / Link / Wallensteen , Peter / 2010

Uppsala universitet Engelska Språket
91-554-0025-6 / Link / Lokrantz , Jessie Thomas / 1973

Uppsala universitet Kulturantropologi
This study deals with the implications of implementing the World Heritage site of Laponia in northern Sweden. Laponia, consisting of previously well-known national parks such as Stora Sjöfallet and Sarek, obtained its World Heritage status in 1996. Both the biological and geological significance of the area and the local Sami reindeer herding culture are included in the justification for World Heritage status. This thesis explores how Laponia became an arena for the long-standing Sami ethno-political struggle for increased self-governance and autonomy. In many other parts of the world, various joint management schemes between indigenous groups and national environmental protection agencies are more and more common, but in Sweden no such agreements between the Swedish Environmental Protection Agency and the Sami community have been tested. The local Sami demanded to have a significant influence, not to say control, over the future management of Laponia. These were demands that were not initially acknowledged by the local and national authorities, and the negotiations about the management of Laponia continued over a period of ten years. This thesis shows how the local Sami initially were marginalized in the negotiations both because of their alleged “difference” and because of their alleged “similarity” to the majority population. By navigating through what can be described as “a politics of difference,” the Sami involved eventually succeeded in articulating their cultural and historical difference in such a way that they were perceived as different but equal in relation to the other actors. By describing the many twist and turns of the negotiations between the local Sami and the local authorities, this thesis shows how the involvement of international agencies and global protection aspirations, such as the World Heritage Convention, might establish a link between the local and international levels that to a certain extent bypasses the national level and empowers indigenous/local peoples and their ethno-political objectives. As such, this study demonstrates how local/indigenous peoples’ involvement in environmental protection work is above all a political issue that ultimately leads to a situation where their relation with the state authorities is reshaped and reassessed.
978-91-554-7656-4 / Link / Green , Carina / 2009

Uppsala universitet Datavetenskap
N/A / Link / Kavathatzopoulos , Iordanis / 1993

Uppsala universitet Samhällsvetenskap
N/A / Link / Magnusson Turner , Lena / 2007

Uppsala universitet Övrigt
N/A / Link / Eriksson , Anders /

Hepatitis C is a global health problem that affects approximately 120–180 million people. This viral infection causes serious liver diseases and the therapy available suffers from low efficiency and severe side effects. Consequently, there is a huge unmet medical need for new therapeutic agents to combat the hepatitis C virus (HCV). Inhibition of the viral NS3 protease has recently emerged as a promising approach to defeat this infection, and the first HCV NS3 protease inhibitors have now entered clinical trials.In this project, several novel HCV NS3 protease inhibitors have been designed, synthesized and biochemically evaluated. Inhibitors with various P1 C-terminal functional groups intended as potential bioisosteres to the carboxylic acid found in product-based inhibitors have been revealed. Special focus has been placed on establishing structure–activity relationships of inhibitors containing the promising P1 C-terminal acyl sulfonamide group. The properties of the acyl sulfonamide functionality that are important for producing potent inhibitors have been identified. In addition, the advantages of the acyl sulfonamide group compared to the carboxylic acid have been demonstrated in both enzymatic and cell-based assays.Besides the acyl sulfonamide functionality, the acyl cyanamide and the acyl sulfinamide groups have been identified as new carboxylic acid bioisosteres in HCV NS3 protease inhibitors.The synthetic work included the development of a fast and convenient methodology for the preparation of aryl acyl sulfonamides. The use of microwave heating and Mo(CO)6 as a solid carbon monoxide source provided aryl acyl sulfonamides from aryl halides in excellent yields. This method was subsequently used in the decoration of novel HCV NS3 protease inhibitors comprising a non-natural P1 moiety. This new class of compounds can be used as lead structures in a future optimization process aimed at producing more drug-like HCV NS3 protease inhibitors.
978-91-554-6862-0 / Link / Rönn , Robert / 2007

Uppsala universitet Pedagogik
N/A / Link / Larsson , Esbjörn / 2006

Uppsala universitet Gamla Testamentets Exegetik
Med utgångspunkt i Bakhtins begrepp dialogicitet diskuteras olika aspekter av den dialogiska karaktären hos texter i Bibeln, i relation till den samtida diskussionen om predikan.
978-91-526-3239-0 / Link / Eidevall , Göran / 2008

Uppsala universitet Pedagogik
978-91-89444-32-4 / Link / Román , Henrik / 2008

Uppsala universitet Pedagogik
N/A / Link / Calander , Finn / 1999

N/A / Link / Williams , Henrik / 2007

Uppsala universitet Nordiska Språk
N/A / Link / Williams , Henrik / 2007

Uppsala universitet Samhällsvetenskap
N/A / Link / Magnusson Turner , Lena / 2007

Uppsala universitet Samhällsvetenskap
N/A / Link / Magnusson Turner , Lena / 2007

Uppsala universitet Samhällsvetenskap
N/A / Link / Magnusson Turner , Lena / 2008

Uppsala universitet Övrigt
N/A / Link / Wallensteen , Peter / 2009

Uppsala universitet Övrigt
978-91-506-2105-1 / Link / Wallensteen , Peter / 2009

In science and technology there is a steadily increased demand of new materials and new materials production processes since they create new application areas as well as improved production technology and economy. This thesis includes development and studies of a chemical vapour deposition (CVD) process for growth of thin films of the metastable material copper nitride, Cu3N, which is a semiconductor and decomposes at around 300 oC. The combination of these properties opens for a variety of applications ranging from solar cells to sensor and information technology.The CVD process developed is based on a metal-organic compound copper hexafluoroacetylacetonate, Cu(hfac)2 , ammonia and water and was working at about 300 oC and  5 Torr. It was found that a small amount of water in the vapour increased the growth rate considerably and that the phase content, film texture, chemical composition and morphology were strongly dependent on the deposition conditions.In-situ oxygen doping during the CVD of Cu3N to an amount of 9 atomic % could also be accomplished by increasing the water concentration in the vapour. Oxygen doping increases the band gap of the material as well as the electrical resistivity and changes the stability. The crystal structure of Cu3N is very open and contains several sites which can be used for doping. Different spectroscopic techniques like X-ray photoelectron spectroscopy, Raman spectroscopy and near edge X-ray absorption fine structure spectroscopy were used to identify the oxygen doping site(s) in Cu3N. Besides the properties, the oxygen doping also affected the morphology and texture of the films.By combining thin layers of different materials several properties can be optimized at the same time. It has been demonstrated in this thesis that multilayers, composed of alternating Cu3N and Cu2O layers, i.e. a metastable and a stable material, could be grown by CVD technique. However, the stacking sequence affected the texture, morphology and chemical composition. The interfaces between the different layers were sharp and no signs of decomposition of the initially deposited metastable Cu3N layer could be detected.
978-91-554-7665-6 / Link / Fallberg , Anna / 2010

Uppsala universitet Samhällsvetenskap
N/A / Link / Bengtsson , Bo / 2005

Uppsala universitet Kulturgeografi, Ekonomisk Geografi
N/A / Link / Ericsson , Urban / 2005